Author

Daniel J. Brogan

University of California San DiegoORCID 0000-0001-6582-8966Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Calvin P. LiniD· 2 shared Elizabeth A. KomivesiD· 2 shared Harry LiiD· 2 shared Omar S. AkbariiD· 2 shared Claire LiniD· 1 shared Elena Dalla BenettaiD· 1 shared Fangying CheniD· 1 shared Tianqi WangiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 32 mutual co-author links

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2 shared papersMolecular Biology

Calvin P. LinORCID

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2 papers

Recent·Most cited

Molecular BiologyJournal of Molecular BiologyPeer-reviewedNov 27, 2025

Synthetic type III-E CRISPR-Cas effectors for programmable RNA-targeting

Daniel J. Brogan, Calvin P. Lin, Elena Dalla Benetta…·Omar S. Akbari

This paper identifies a novel type III-E-like CRISPR-Cas effector composed of Cas7-like and Cas1-like domains, demonstrating its RNA-targeting capability and modularity for engineering synthetic Cas effectors.

4 citations

CRISPR screenexperimental assay

𝕏 PostBluesky

BiophysicsNucleic Acids ResearchPeer-reviewedApr 10, 2025

CRISPR RNA binding drives structural ordering that primes Cas7-11 for target cleavage

Calvin P. Lin, Harry Li, Daniel J. Brogan…·Elizabeth A. Komives

This study investigates how crRNA binding induces structural changes in Cas7-11, revealing its conformational dynamics and how these changes regulate its function.

5 citations

experimental assayprotein folding & dynamics

𝕏 PostBluesky