Harry Li

This paper identifies a novel type III-E-like CRISPR-Cas effector composed of Cas7-like and Cas1-like domains, demonstrating its RNA-targeting capability and modularity for engineering synthetic Cas effectors.

This paper shows that the ASB9-CRL ubiquitin ligase polyubiquitylates histones H3 and H4, but not H2A and H2B, and that this process requires ARIH2 and occurs only on free histones.

This study investigates how crRNA binding induces structural changes in Cas7-11, revealing its conformational dynamics and how these changes regulate its function.