Elizabeth A. Komives

The paper investigates how NFκB (RelA/p50) achieves high-affinity binding to partial consensus DNA sequences through structural rearrangements and dynamic interactions.

This paper designs de novo minibinders that inhibit blood-stage malaria replication with nanomolar potency by targeting the RH5-basigin interaction.

This study reveals the conformational dynamics of Tom70 through structural and computational analyses, showing how its allosteric network coordinates mitochondrial protein import and is modulated by viral interactions.

This paper identifies a novel type III-E-like CRISPR-Cas effector composed of Cas7-like and Cas1-like domains, demonstrating its RNA-targeting capability and modularity for engineering synthetic Cas effectors.

This paper shows that the ASB9-CRL ubiquitin ligase polyubiquitylates histones H3 and H4, but not H2A and H2B, and that this process requires ARIH2 and occurs only on free histones.

This study investigates how crRNA binding induces structural changes in Cas7-11, revealing its conformational dynamics and how these changes regulate its function.

This study investigates how NF-κB interacts with H3nuc and CENP-Anuc, finding that it unravels H3nuc but not CENP-Anuc.

This study compares the reaction mechanisms of two IDH1 mutants, finding that R132Q has optimized active site conformation for both conventional and neomorphic activity, potentially explaining resistance to inhibitors.