Author

Oliver J. Irving

University of BirminghamORCID 0000-0001-6617-2436Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:variant calling· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:protein design· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Tim AlbrechtiD· 2 shared Cengiz J. Khan· 1 shared Robert K. NeelyiD· 1 shared Samuel Stone· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

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2 shared papersSynthetic Biology

Tim AlbrechtORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintJun 18, 2026

3' Exonuclease-mediated DNA assembly at room temperature and below

Oliver J. Irving, Cengiz J. Khan, Tim Albrecht

This paper introduces 3LTDA, a low-temperature DNA assembly method that preserves 5' modifications and outperforms conventional Gibson Assembly in efficiency and functionality retention.

DOI 10.64898/2026.06.17.732819

DNA methylationwhole-genome sequencing

𝕏 PostBluesky

GenomicsbioRxivPreprintApr 10, 2025

A modified methyl transferase cofactor to selectively disable gene expression in E. coli

Oliver J. Irving, Samuel Stone, Robert K. Neely, Tim Albrecht

The paper demonstrates that AdoHcy azide modification selectively disables gene expression in E. coli by causing transcriptional steric inhibition.

DOI 10.1101/2025.04.10.648196

E. coliDNA methylation

𝕏 PostBluesky