The SARS-CoV-2 spike receptor-binding domain has evolved decreased inherent antigenicity in humans
Catherine Jacob-Dolan, Jim B. Boonyaratanakornkit, Jesse D. Bloom
The study shows that SARS-CoV-2 variants have reduced the ability of human naive B cells to recognize the RBD compared to the original Wuhan-Hu-1 variant.
bioRxiv · Oct 16, 2026 · PreprintMicrobiology