Evolution of an amniote-specific mechanism for modulating ubiquitin signalling via phosphoregulation of the E2 enzyme UBE2D3
Mónica Román-Trufero, Constance M Ito, Conrado Pedebos, Indiana Magdalou, Yi-Fang Wang, Mohammad Mahdi Karimi, Benjamin Moyon, Zoë Webster, Aida Di Gregorio, Véronique Azuara, Syma Khalid, Christian Speck, Tristan A. Rodríguez, Niall Dillon
The paper identifies a conserved serine in UBE2D3 that, when phosphorylated by Aurora B, reduces UBE2D3 levels and affects early embryonic development in mice.
Molecular Biology and Evolution · Mar 3, 2020Peer-reviewedDevelopmental Biology