Author

Aida Di Gregorio

Hammersmith Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Developmental Biology· 4

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Tristan A. RodrígueziD· 4 shared Ana LimaiD· 3 shared Salvador Pérez-MonteroiD· 3 shared Sarah BowlingiD· 3 shared Bárbara PernauteiD· 2 shared Mohammad Mahdi KarimiiD· 2 shared Adrian Perez BarretoiD· 1 shared Alejandra TomásiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

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10 top collaborators · 37 mutual co-author links

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4 shared papersDevelopmental Biology

Tristan A. RodríguezORCID

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4 papers

Recent·Most cited

Sensing of extracellular L-Proline availability by the integrated stress response determines the outcome of cell competition.

Shruthi Krishnan, Ana Lima, Sizhe Tan, Ying Thong Low, Salvador Pérez-Montero, Aida Di Gregorio, Adrian Perez Barreto, Sarah Bowling, Karen H. Vousden, Tristan A. Rodríguez

The paper shows that winner cells in cell competition induce L-Proline uptake in loser cells, repressing the integrated stress response and leading to their elimination.

Science Advances · Jul 9, 2025Peer-reviewedDevelopmental Biology

Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development

Ana Lima, Gabriele Lubatti, Jörg Patrick Burgstaller, Di Hu, Alistair P. Green, Aida Di Gregorio, Tamzin Zawadzki, Bárbara Pernaute, Elmir Mahammadov, Salvador Pérez-Montero, Marian H. Dore, Juan Miguel Sánchez, Sarah Bowling, Margarida Sancho, Thomas Kolbe, , Tristan A. Rodríguez

The paper identifies mitochondrial defects in eliminated cells during early mouse development and shows that cell competition removes cells with mitochondrial DNA mutations and sequence changes.

Nature Metabolism · Jul 12, 2021Peer-reviewedDevelopmental Biology

Evolution of an amniote-specific mechanism for modulating ubiquitin signalling via phosphoregulation of the E2 enzyme UBE2D3

Mónica Román-Trufero, Constance M Ito, Conrado Pedebos, Indiana Magdalou, Yi-Fang Wang, Mohammad Mahdi Karimi, Benjamin Moyon, Zoë Webster, Aida Di Gregorio, Véronique Azuara, Syma Khalid, Christian Speck, Tristan A. Rodríguez, Niall Dillon

The paper identifies a conserved serine in UBE2D3 that, when phosphorylated by Aurora B, reduces UBE2D3 levels and affects early embryonic development in mice.

Molecular Biology and Evolution · Mar 3, 2020Peer-reviewedDevelopmental Biology

DRP1-mediated regulation of mitochondrial dynamics determines the apoptotic response upon embryonic differentiation.

Bárbara Pernaute, Juan Miguel Sánchez Nieto, Salvador Pérez-Montero, Aida Di Gregorio, Ana Lima, Katerina Lawlor, Sarah Bowling, Gianmaria Liccardi, Alejandra Tomás, Pascal Meier, Guy A. Rutter, Ivana Barbaric, Tristan A. Rodríguez

This study identifies DRP1-mediated mitochondrial dynamics as a regulator of apoptotic response during embryonic differentiation in mouse cells.

bioRxiv · Nov 8, 2019 · PreprintDevelopmental Biology