Author

Zhikai Wang

Shanghai Jiao Tong UniversityORCID 0000-0001-6646-8763Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

Fangzhou LouiD· 3 shared Siyu Deng· 3 shared Xiaojie CaiiD· 3 shared Fengjiao Zhang· 2 shared Honglin WangiD· 2 shared Qingqing Shen· 2 shared Xiangxiao Li· 2 shared Yang SuniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersImmunology

Fangzhou LouORCID

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3 papers

Recent·Most cited

Transplanting ANXA1- CD8+ Naive T cells Delay Aging Through Senolysis

Yue Wu, Shang Zhi Guo, Fengjiao Zhang, Fangzhou Lou, Y Y Li, Yang Sun, Qingqing Shen, Liuqi Zhao, Xiaojie Cai, Zhikai Wang, Qing Yang, Xichen Zheng, Min Gao, Xiangxiao Li, Siyu Deng, , Hao Wang

This study shows that transplanting ANXA1-negative CD8 naive T cells extends lifespan and improves health in aged mice by reducing senescence.

bioRxiv · Feb 23, 2026 · PreprintImmunology

Pp6-Pfkfb1 axis modulates intracellular bacterial proliferation by orchestrating host-pathogen metabolic crosstalk

Li Fan, Yang Sun, Fangzhou Lou, Zilong Fang, Wen Ding, Xiangxiao Li, Yan Li, Qingqing Shen, Siyu Deng, Jihuan Liang, Fengjiao Zhang, Sibei Tang, Zhikai Wang, Xiaojie Cai, Jiajia Tong, , Honglin Wang

This study identifies the Pp6-Pfkfb1 axis as a key regulator of host-pathogen metabolic crosstalk that modulates intracellular bacterial proliferation in Salmonella-infected macrophages.

PLoS Pathogens · Dec 31, 2025Peer-reviewedMicrobiology

CCR7+ Dendritic Cells Define a Type 17 Module in Psoriasis

Yang Sun, Fangzhou Lou, Xiaojie Cai, Zhikai Wang, Xiuli Yang, Libo Sun, Zhenyao Xu, Siyu Deng, Zhouwei Wu, Zhaoyuan Liu, Yuling Shi, Florent Ginhoux, Honglin Wang

The paper identifies CCR7+ dendritic cells as the primary source of IL-23 in psoriasis, linking them to type 17 inflammation and relapse.

Nature Communications · Aug 15, 2025Peer-reviewedImmunology