Zhenyu Zhang

The paper introduces QAG, a method to improve LLM accuracy for somatic variant frequencies by integrating with the Genomic Data Commons.

The paper describes the pipelines and workflows used to process and harmonize genomic data in the NCI Genomic Data Commons, including data types like somatic mutations and gene expression.

The paper identifies cancer-specific eQTLs by modeling genotype-tumor purity interactions in heterogeneous tumor gene expression data, showing most risk variants affect tumor microenvironment cells.