Author

Zhenyu Zhang

Shenzhen Bay Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

Changzheng DuiD· 3 shared Fanglei Gong· 3 shared Kun SuniD· 3 shared Mengqi YangiD· 3 shared Wanqiu WangiD· 3 shared Bianbian Tang· 2 shared Huizhen Lin· 2 shared Xiaoyi LiuiD· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Changzheng DuORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Influenza virus antagonizes self sensing by RIG-I to enhance viral replication

Mitchell P. Ledwith, Thomas Nipper, Kaitlin A. Davis, Deniz Üresin, Zhenyu Zhang, Mariel Kleer, Denys A. Khaperskyy, Craig McCormick, Anastassia V. Komarova, Andrew Mehle

This study shows influenza virus uses its nucleoprotein to block RIG-I activation by host RNAs, thereby suppressing the antiviral response and enhancing viral replication.

Cell Reports · Oct 30, 2026Peer-reviewedMicrobiology

Isolation and Characterization of a Novel Calcium-Precipitating Alkali-Tolerant Lysinibacillus sphaericus in Local Urban Environment

Kah Wee Tan, Soon Keong Wee, Aden Yeoh, Zhenyu Zhang, Kang Hai Tan, P. H. Yap

This study isolates and characterizes a novel alkali-tolerant Lysinibacillus sphaericus strain capable of calcium carbonate precipitation, showing potential for concrete crack repair.

bioRxiv · Jan 23, 2026 · PreprintMicrobiology

Cancer-like fragmentomic characteristics of somatic variants in cell-free DNA

Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Wanqiu Wang, Yunxia Bai, Yu Zhao, Yu Zhao, Changzheng Du, Kun Sun

This study identifies cancer-like fragmentomic traits in somatic variants of cfDNA, enabling cancer diagnosis through integrative genomic and fragmentomic analysis using AI models.

Advanced Science · Jan 22, 2026Peer-reviewedCancer Biology

Host Phosphatase PPM1G Governs Influenza vRNP Homeostasis by Orchestrating NP Phosphorylation Dynamics and Autophagy

Mengmeng Yu, Yuxing Qu, Liuke Sun, Zhenyu Zhang, Rongkuan Sun, Xing Guo, Huiling Ren, Xiaojun Wang

This study identifies PPM1G as a host phosphatase that regulates influenza vRNP homeostasis by modulating NP phosphorylation and autophagy.

bioRxiv · Sep 18, 2025 · PreprintMicrobiology

Cell-free DNA fragmentomic characteristics in transposon elements inform molecular regulators and enhance cancer diagnosis

Fanglei Gong, Yuqi Pan, Huizhen Lin, Yunyun An, Mengqi Yang, Xiaoyi Liu, Yunxia Bai, Wanqiu Wang, Zhenyu Zhang, Bianbian Tang, Kun Zhang, Xin Zhao, Yu Fen Zhao, Changzheng Du, Xuetong Shen, Kun Sun

This study identifies cfDNA fragmentomic features in transposon elements as biomarkers for cancer diagnosis, showing improved performance over genome-wide measurements.

bioRxiv · Jul 10, 2025 · PreprintCancer Biology

Candida albicans drives colorectal cancer progression by inducing hypoxia signaling

Wanqiu Wang, Mengqi Yang, Fanglei Gong, Zhenyu Zhang, Yanping Ma, Haihuang Li, Yu Zhao, Changzheng Du, Ningning Li, Guiwei He, Kun Sun

This study shows Candida albicans promotes colorectal cancer by activating hypoxia signaling through EGFR/TLR2 pathways.

bioRxiv · Dec 25, 2024 · PreprintCancer Biology