BiophysicsACS Chemical BiologyPeer-reviewed
Dynamic Pathway of Guanidine-III Riboswitch Folding Revealed by Single-Molecule FRET: Mg2+-Assisted Preorganization and Ligand-Induced Kinetic Trapping
Mengke Jiang, Yunqiang Bian, Lujun Zou…·Hai Pan
This study uses smFRET and MD simulations to reveal the dynamic conformational changes of the guanidine-III riboswitch, showing how Mg2+ and ligand binding stabilize and trap its folded state.
DOI 10.1021/acschembio.5c00293