Author

Alexander P. Sobinoff

Children's Medical Research InstituteORCID 0000-0001-6679-5211Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:proteomics· 1

Frequent Co-Authors

Hilda A. PickettiD· 2 shared Jixuan GaoiD· 2 shared Andrew J. DeansiD· 1 shared Christopher B. NelsoniD· 1 shared Ekaagra KesarwaniiD· 1 shared Heide L. FordiD· 1 shared Jadon WellsiD· 1 shared Karen L. MacKenzieiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Hilda A. PickettORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJan 19, 2025

Potent synthetic lethality between PLK1 and EYA-family inhibitors in tumours of the central and peripheral nervous system

Christopher B. Nelson, Jadon Wells, Ekaagra Kesarwani…·Hilda A. Pickett

This study shows that combining EYA and PLK1 inhibitors is effective in treating neurological cancers by inducing cell death and targeting cancer stem cells.

DOI 10.1101/2025.01.19.633804

humanbulk RNA-seq

𝕏 PostBluesky

BiochemistryNucleic Acids ResearchPeer-reviewedAug 9, 2024

Mechanism of structure-specific DNA binding by the FANCM branchpoint translocase

Lara Abbouche, Vincent J. Murphy, Jixuan Gao…·Andrew J. Deans

This study identifies the Hel2i domain as essential for FANCM's DNA binding and branch migration, revealing its role in suppressing the ALT pathway in cancer cells.

9 citations

humanDNA methylation

𝕏 PostBluesky