Author

Giuseppe Astarita

Denali Therapeutics (United States)ORCID 0000-0001-6700-301XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Anarmaa MendsaikhaniD· 1 shared Anastasia G. HenryiD· 1 shared Annie ArguelloiD· 1 shared Anthony A. EstradaiD· 1 shared Audrey Cheuk-Nga Ho· 1 shared Bonne M. ThompsoniD· 1 shared Chi‐Lu Chiu· 1 shared Christopher J. HolleriD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperNeuroscience

Anarmaa MendsaikhanORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

NeuroscienceMolecular NeurodegenerationPeer-reviewedAug 6, 2025

LRRK2 Kinase Activity Regulates Parkinson's Disease-Relevant Lipids at the Lysosome

Michael T. Maloney, Xiang Wang, Rajarshi Ghosh…·Anastasia G. Henry

This study shows that LRRK2 kinase activity affects BMP and GSL levels in lysosomes, linking lysosomal dysfunction to Parkinson's disease through changes in GCase activity and BMP accumulation.

18 citationstop 2%

humanexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 17, 2023

Granulins rescue inflammation, lysosome dysfunction, and neuropathology in a mouse model of progranulin deficiency.

Jessica T. Root, Anarmaa Mendsaikhan, Srijita Nandy…·Thomas L. Kukar

This study shows that individual granulins can rescue disease pathology in PGRN-deficient mice, suggesting they are functional units of PGRN with therapeutic potential.

11 citations

mouseexperimental assay

𝕏 PostBluesky