Author

Jessica T. Root

National Institutes of HealthORCID 0000-0002-9150-9579Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2

Frequent Co-Authors

Linda G. YangiD· 3 shared Priyanka S. NarayaniD· 3 shared Adrian LitaiD· 2 shared Carla Cuní‐LópeziD· 2 shared Christian A. CombsiD· 2 shared Georgia TayloriD· 2 shared Mark CooksoniD· 2 shared Mioara LarioniD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

Linda G. YangORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

APOE genotypes differentially remodel the astrocytic lipiddroplet-associated proteome to shape lipid droplet dynamics

Carla Cuní‐López, Jessica T. Root, Ying Hao, Niek Blomberg, Sascha Koppes-den Hertog, Dylan C. Sacks, Amber E. Trujillo, Rodolfo Ghirlando, Isabelle Kowal, Jacob Epstein, Linda G. Yang, Mark Cookson, Elise Marsan, Rik van der Kant, Martin A. Giera, , Priyanka S. Narayan

This study shows APOE genotypes alter astrocytic lipid droplet proteomes and dynamics, with APOE4 showing resistance to lipophagy, suggesting impaired clearance as a mechanism for AD risk.

Nature Communications · Aug 19, 2026Peer-reviewedCell Biology

APOE4 and INPP5D converge on membrane mechanics to regulate endocytosis in human astrocytes

Artur S. Gevorgyan, Lila M Gordon, Christian A. Combs, Adrian Lita, Linda G. Yang, Carla Cuní‐López, Jessica T. Root, Mioara Larion, Justin W. Taraska, Priyanka S. Narayan

This study shows APOE4 impairs endocytosis in astrocytes by altering membrane mechanics, and INPP5D restores this process by promoting clathrin curvature and maturation.

bioRxiv · May 25, 2026 · PreprintCell Biology

Triglyceride metabolism controls inflammation and APOE4-associated disease states in microglia

Roxan A. Stephenson, Jordy Sepulveda, Kory R. Johnson, Adrian Lita, Jaanam Gopalakrishnan, Dominic J. Acri, Alexandra G. Beilina, Linling Cheng, Linda G. Yang, Jessica T. Root, Michael Emmerson Ward, Christian A. Combs, William C. Skarnes, Mark Cookson, Han‐Yu Shih, , Priyanka S. Narayan

This study shows that triglyceride metabolism is essential for microglial activation and disease states in APOE4 microglia, with implications for modulating immune responses.

Cell Reports · Jul 1, 2025Peer-reviewedCell Biology

Granulins rescue inflammation, lysosome dysfunction, and neuropathology in a mouse model of progranulin deficiency.

Jessica T. Root, Anarmaa Mendsaikhan, Srijita Nandy, Georgia Taylor, Minzheng Wang, Ludmilla Troiano Araujo, Paola Merino, Danny Ryu, Christopher J. Holler, Bonne M. Thompson, Giuseppe Astarita, Jean‐François Blain, Thomas L. Kukar

This study shows that individual granulins can rescue disease pathology in PGRN-deficient mice, suggesting they are functional units of PGRN with therapeutic potential.

bioRxiv · Apr 17, 2023 · PreprintNeuroscience

Proximity-based labeling reveals DNA damage-induced N-terminal phosphorylation of fused in sarcoma (FUS) leads to distinct changes in the FUS protein interactome.

Michelle A. Johnson, Thomas A. Nuckols, Paola Merino, Pritha Bagchi, Srijita Nandy, Jessica T. Root, Georgia Taylor, Nicholas T. Seyfried, Thomas L. Kukar

The paper investigates how N-terminal phosphorylation of FUS affects its protein interactome using proximity labeling and mass spectrometry, revealing distinct interactome changes and functional consequences.

bioRxiv · Jun 11, 2021 · PreprintNeuroscience