Author

Thomas L. Kukar

Emory UniversityORCID 0000-0002-3750-6262Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Georgia TayloriD· 2 shared Jessica T. RootiD· 2 shared Paola MerinoiD· 2 shared Srijita NandyiD· 2 shared Anarmaa MendsaikhaniD· 1 shared Bonne M. ThompsoniD· 1 shared Christopher J. HolleriD· 1 shared Danny Ryu· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Georgia TaylorORCID

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2 papers

Recent·Most cited

Granulins rescue inflammation, lysosome dysfunction, and neuropathology in a mouse model of progranulin deficiency.

Jessica T. Root, Anarmaa Mendsaikhan, Srijita Nandy, Georgia Taylor, Minzheng Wang, Ludmilla Troiano Araujo, Paola Merino, Danny Ryu, Christopher J. Holler, Bonne M. Thompson, Giuseppe Astarita, Jean‐François Blain, Thomas L. Kukar

This study shows that individual granulins can rescue disease pathology in PGRN-deficient mice, suggesting they are functional units of PGRN with therapeutic potential.

bioRxiv · Apr 17, 2023 · PreprintNeuroscience

Proximity-based labeling reveals DNA damage-induced N-terminal phosphorylation of fused in sarcoma (FUS) leads to distinct changes in the FUS protein interactome.

Michelle A. Johnson, Thomas A. Nuckols, Paola Merino, Pritha Bagchi, Srijita Nandy, Jessica T. Root, Georgia Taylor, Nicholas T. Seyfried, Thomas L. Kukar

The paper investigates how N-terminal phosphorylation of FUS affects its protein interactome using proximity labeling and mass spectrometry, revealing distinct interactome changes and functional consequences.

bioRxiv · Jun 11, 2021 · PreprintNeuroscience