NeurosciencebioRxivPreprint
Granulins rescue inflammation, lysosome dysfunction, and neuropathology in a mouse model of progranulin deficiency.
Jessica T. Root, Anarmaa Mendsaikhan, Srijita Nandy…·Thomas L. Kukar
This study shows that individual granulins can rescue disease pathology in PGRN-deficient mice, suggesting they are functional units of PGRN with therapeutic potential.
11 citations