Molecular BiologyMolecular Therapy — Methods & Clinical DevelopmentPeer-reviewed
Unveiling Genomic Rearrangements in Engineered iPSC Lines by Optical Genome Mapping
Darren Finlay, Pooja Hor, Benjamin Goldenson…·Kristiina Vuori
This study uses optical genome mapping to detect genomic rearrangements in gene-edited iPSCs, showing that transposons and lentiviral methods cause more insertions than CRISPR-Cas9.
DOI 10.1016/j.omtm.2025.101644