Kristiina Vuori

Disrupting a Convergent Acetylation Circuit Collapses Leukemic Identity Across AML Subtypes

This paper identifies an acetylation-dependent circuit controlling SEC integrity in AML, showing that disrupting KAT2A/B leads to broad anti-leukemic effects across subtypes.

Unveiling Genomic Rearrangements in Engineered iPSC Lines by Optical Genome Mapping

This study uses optical genome mapping to detect genomic rearrangements in gene-edited iPSCs, showing that transposons and lentiviral methods cause more insertions than CRISPR-Cas9.

SUMO2 Inhibition Reverses Aberrant Epigenetic Rewiring Driven by Synovial Sarcoma Fusion Oncoproteins and Impairs Sarcomagenesis

This study identifies SUMO2 as a selective vulnerability in synovial sarcoma, showing that SUMO2 inhibition reverses SS18-SSX-driven gene expression and impairs tumor growth.

Age-associated modulation of TREM1/2- expressing macrophages promotes melanoma progression and metastasis

This study shows that aging alters macrophage phenotypes in the melanoma microenvironment, with TREM1 and TREM2 playing distinct roles in tumor progression and metastasis in aged mice.