Author

Pengfei Guo

University of PennsylvaniaORCID 0000-0001-6734-6549Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Assay:Hi-C· 2 Organism:mouse· 2 Research Focus:spatial domain detection· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Yanxiang DengiD· 2 shared Abraham J. WaldmaniD· 1 shared Angelysia Cardilla· 1 shared Chin Nien LeeiD· 1 shared Jennifer E. Phillips‐CreminsiD· 1 shared Jiaxin ZhuiD· 1 shared Jincan He· 1 shared Jingtian ZhouiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenomics

Yanxiang DengORCID

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2 papers

Recent·Most cited

GenomicsCellPeer-reviewedAug 25, 2026

Integrative spatial profiling of 3D genome organization and gene expression in tissue

Pengfei Guo, Yan Cui, Jincan He…·Yanxiang Deng

This paper introduces Spatial Hi-C-RNA, a spatial multi-omics technology that co-maps chromatin conformation and transcriptome in tissue, revealing spatially coherent domains and new insights into gene regulation.

DOI 10.1016/j.cell.2026.07.039

mousehuman

𝕏 PostBluesky

GeneticsNature MethodsPeer-reviewedJan 27, 2025

Multiplexed spatial mapping of chromatin features, transcriptome, and proteins in tissues

Pengfei Guo, Liran Mao, Yu‐Fan Chen…·Yanxiang Deng

The paper introduces spatial-Mux-seq, a multi-modal spatial technology that profiles five modalities in tissues, revealing new insights into cell types, gene regulation, and epigenetic gradients in mouse embryos and brains.

70 citationstop 1%

mouseChIP-seq

𝕏 PostBluesky