Abraham J. Waldman

This paper introduces Spatial Hi-C-RNA, a spatial multi-omics technology that co-maps chromatin conformation and transcriptome in tissue, revealing spatially coherent domains and new insights into gene regulation.

The paper tests nine ASD-linked transcription regulators in neurons, finding shared gene expression disruptions and firing pattern changes.

The paper identifies persistent chromatin loops in hippocampal neurons after fear conditioning that correlate with gene expression changes during memory recall.

The paper shows that persistent chromatin loops in human neurons influence gene expression plasticity during and after stimulation, with some loops maintaining repression or activation for up to five days.

The paper identifies multi-loop chromatin miswiring in FAD-mutant neurons that correlates with gene expression changes and DLX transcription factor activity.