Linda B. Buck

This study identifies distinct olfactory pathways to appetite-regulating neurons in the hypothalamus, showing differential input to AgRP and POMC neurons.

The paper shows that certain odorants can block stress hormone responses to various stressors in mice by inhibiting hypothalamic neurons involved in stress signaling.

Connect-seq combines viral tracing and single-cell transcriptomics to map molecular identities and signaling molecules in neural circuits, revealing upstream neuron subsets and their anatomical locations in the hypothalamus.