Luís R. Saraiva

This study uses spatial transcriptomics to map gene expression patterns of gut sensory cells, revealing regional differences in hormone, neurotransmission, immune, and nutrient sensing genes along the gastrointestinal tract.

The paper predicts the mechanistic impacts of human protein missense variants on stability, protein-protein interactions, and small-molecule binding using AlphaFold2 structures.

This study shows that short-term consumption of ultra-processed semi-synthetic diets impairs olfactory function and brain metabolism in mice.

The paper identifies a common mechanism for singular gene expression in odorant receptors by analyzing transgenic mice with enhanced OR1A1 expression.

This paper creates a 3D spatial transcriptomics atlas of the mouse olfactory mucosa, revealing spatial gene distribution patterns and supporting the chromatographic theory of olfaction.

This study creates a comprehensive mouse olfactory ethological atlas using behavioral responses to 73 odorants, revealing shared properties between mouse and human olfactory perception.

The paper shows that certain odorants can block stress hormone responses to various stressors in mice by inhibiting hypothalamic neurons involved in stress signaling.

The paper examines gene expression changes across multiple organs during short-term fasting in mice, identifying a brain-liver-fats network with significant immune system regulation.

This study creates a transcriptomic atlas of olfactory mucosae across species to show evolutionary patterns in odor detection capabilities.

The paper compares olfactory preferences across flies, mice, and humans, finding positive correlation between flies and mice, negative correlation between flies and humans, and no evidence of shared preferences between humans and mice.

The paper uses single-cell RNA sequencing to reveal heterogeneity in murine hypothalamic POMC neurons, identifying distinct subpopulations with different gene expression profiles and receptor expression.