Michael Chong

ERICH-GENE collects and analyzes genomic and neuroimaging data from over 10,000 multi-ethnic ICH cases to identify genetic risk factors and trans-ethnic variation in ICH.

This study identifies 73 genetic loci associated with blood mitochondrial DNA copy number and suggests a causal link between low mtDNA-CN and dementia risk.

The paper develops a method to create calibrated rare variant genetic risk scores using exome data, showing strong association with coronary artery disease risk.

This paper introduces MonsterLM, a method for estimating gene-by-environment interactions on large datasets, finding significant interaction variance and improved polygenic score prediction.

This study uses Mendelian randomization to assess the effects of genetically elevated free testosterone on 23 health outcomes, finding both clinical benefits and adverse effects.

The paper analyzes genetic variants at the PCSK9 locus to assess their phenotypic effects on lipid levels and disease outcomes, finding concordance with PCSK9 inhibitor trials for myocardial infarction but discordance for type 2 diabetes.