Author
Institut universitaire de cardiologie et de pneumologie de QuébecORCID 0000-0002-2395-2333Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Ana Villaplana-Velasco, Nicolas Perrot, Yu Hang…·Marie Pigeyre
Michael Chong, Pedrum Mohammadi‐Shemirani, Nicolas Perrot…·Guillaume Paré
This study identifies 73 genetic loci associated with blood mitochondrial DNA copy number and suggests a causal link between low mtDNA-CN and dementia risk.
Nicolas Perrot, William Pelletier, Jérôme Bourgault…·Benoît J. Arsenault
This study uses trans-omic Mendelian randomization to identify genes, proteins, and metabolites associated with parental lifespan and potential drug targets for healthspan extension.
Mohammad Daud Khan, Matteo Di Scipio, Conor S. Judge…·Guillaume Paré
This paper introduces MonsterLM, a method for estimating gene-by-environment interactions on large datasets, finding significant interaction variance and improved polygenic score prediction.
Benoît J. Arsenault, William Pelletier, Yannick Kaiser…·S. Matthijs Boekholdt
This study investigates the association between elevated Lp(a) levels, parental lifespan, and long-term mortality risk using genetic and observational data.
Nicolas Perrot, Donato Moschetta, S. Matthijs Boekholdt…·Benoît J. Arsenault
This study shows genetic inhibition of PCSK9 lowers lipoprotein levels and reduces risk of CAD and CAVS, with PCSK9 present in calcified aortic valves and induced by oxidative stress.