Guillaume Paré

Design-informed Size Factor Estimation

The paper introduces disize, a normalization method that uses experimental design information to improve size factor estimation in RNA-seq data, showing better accuracy in challenging scenarios.

Biobank-scale survey of gene-diet interactions informs precision nutrition polygenic scores

The paper assesses gene-diet interactions in UK Biobank data to derive polygenic scores that associate with cardiometabolic outcomes and clinical conditions like gout.

The Ethnic/Racial Variations of Intracerebral Hemorrhage Genetics (ERICH-GENE) Study Protocol

ERICH-GENE collects and analyzes genomic and neuroimaging data from over 10,000 multi-ethnic ICH cases to identify genetic risk factors and trans-ethnic variation in ICH.

Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry

The paper develops a DNA methylation score to quantify the impact of maternal smoking on newborn health outcomes in European and South Asian populations, finding consistent associations with smaller birth size and lower birth weight.

Proteome-wide Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiometabolic diseases and longevity

The Genetic Risk of Gestational Diabetes in South Asian women

This study finds that a type 2 diabetes polygenic risk score is strongly associated with gestational diabetes-related traits in South Asian women, accounting for a significant portion of the population attributable fraction.

Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

GWAS and ExWAS of blood Mitochondrial DNA copy number identifies 73 loci and highlights a potential causal role in dementia

This study identifies 73 genetic loci associated with blood mitochondrial DNA copy number and suggests a causal link between low mtDNA-CN and dementia risk.

Calibrated rare variant genetic risk scores for complex disease prediction using large exome sequence repositories

The paper develops a method to create calibrated rare variant genetic risk scores using exome data, showing strong association with coronary artery disease risk.

A versatile, fast and unbiased method for estimation of gene-by-environment interaction effects on biobank-scale datasets

This paper introduces MonsterLM, a method for estimating gene-by-environment interactions on large datasets, finding significant interaction variance and improved polygenic score prediction.

Clinical benefits and adverse effects of genetically-elevated free testosterone levels: a Mendelian randomization analysis

This study uses Mendelian randomization to assess the effects of genetically elevated free testosterone on 23 health outcomes, finding both clinical benefits and adverse effects.

Genome-wide association study identifies 48 common genetic variants associated with handedness.

This study identifies 48 genetic variants associated with handedness using a large GWAS, highlighting polygenic nature and genetic links to neuropsychiatric traits.

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

The paper analyzes genetic variants at the PCSK9 locus to assess their phenotypic effects on lipid levels and disease outcomes, finding concordance with PCSK9 inhibitor trials for myocardial infarction but discordance for type 2 diabetes.

Genome-Wide Polygenic Risk Scores and prediction of Gestational Diabetes in South Asian Women

This study develops polygenic risk scores for gestational diabetes in South Asian women using multi-ethnic summary statistics and validates them in UK Biobank data, finding moderate heritability.

Analytical strategies to include the X-chromosome in variance heterogeneity analyses: evidence for trait-specific polygenic variance structure

The paper investigates X-chromosome variance heterogeneity in quantitative traits using generalized Levene's test and sex-stratified analysis, finding possible polygenic structure for human height variance.

Genetics of fasting indices of glucose homeostasis using GWIS unravels tight relationships with inflammatory markers

The paper uses GWIS to analyze genetic correlations between HOMA-B/-IR and inflammatory markers, identifying novel loci and strong genetic links with PAI-1 and C-reactive protein.

A robust method to estimate regional polygenic correlation identifies heterogeneity in the shared heritability between complex traits

The paper introduces a method to estimate regional polygenic correlation between complex traits and finds heterogeneity in shared heritability across genomic regions.

A machine-learning heuristic to improve gene score prediction of polygenic traitsShort title: Machine-learning boosted gene scores

This paper introduces GraBLD, a machine-learning heuristic that improves polygenic risk scores for height, BMI, and diabetes using summary statistics from large-scale genome-wide studies.