Humanized Bone Marrow-Liver-Thymus Mice for Studying HIV-1 Persistence in Liver and Lung CD4+ T and Myeloid Cell Subsets during Antiretroviral Therapy
Amélie Cattin, Tram N. Q. Pham, Jonathan Dias, Natalia Fonseca do Rosário, Laurence Raymond Marchand, Olga Volodina, Jean-Victor Guimond, Natacha Patey, Yuanyi Li, Kathie Béland, Mohammad-Ali Jenabian, Jérôme Estaquier, Élie Haddad, Éric A. Cohen, Petronela Ancuța
This study uses humanized mice to compare HIV-1 persistence in liver/lung macrophages and CD4+ T-cells during ART, finding macrophages contribute less to viral reservoirs than T-cells.
bioRxiv · Jan 31, 2025 · PreprintImmunology