Author
Scripps Research InstituteORCID 0000-0001-6772-8870Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Anna M. Romanov, Grant A. Knappe, Larance Ronsard…·Darrell J. Irvine
DNA origami particles displaying eOD-GT8 with a synthetic T helper epitope gave antigen-focused germinal centers and expanded VRC01-class precursors in humanized mice after one immunization.
Jiachen Huang, Olivia M. Swanson, Kimmo I. Rantalainen…·Andrew B. Ward
This paper uses cryoEM to analyze antibody-antigen interactions with HIV MPER-GT immunogens, revealing binding patterns and epitopes that inform antigen optimization.
Parham Ramezani-Rad, Christopher A. Cottrell, Ester Marina-Zárate…·William R. Schief
Membrane-bound BG505 MD39.3 Env trimer delivered as mRNA-LNP reduced base-directed antibody responses in rabbits and macaques and elicited neutralizing antibodies, with memory B cell responses documented in macaques.
Kimmo I. Rantalainen, Alessia Liguori, Gabriel Ozorowski…·William R. Schief
The paper presents a nanodisc platform for assembling transmembrane glycoproteins into vaccine candidates, demonstrating its utility in HIV vaccine development through structural and functional analyses.
Gregory M. Martin, Rebecca A Russell, Philipp Mundsperger…·Quentin James Sattentau
This study shows that chemical cross-linking with EDC stabilizes HIV-1 Env trimers without significant structural distortion, improving their stability, morphology, antigenicity, and immunogenicity for vaccine development.