Author

Gregory M. Martin

Scripps Research InstituteORCID 0000-0002-2913-9108Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:protein structure prediction· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:protein structure· 1

Frequent Co-Authors

Andrew B. WardiD· 2 shared Alessia LiguoriiD· 1 shared Bruno E. CorreiaiD· 1 shared Danny LuiD· 1 shared Dennis R. BurtoniD· 1 shared Dietmar KatingeriD· 1 shared Edith E. Schermer· 1 shared Gabriella ScarlattiiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Andrew B. WardORCID

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2 papers

Recent·Most cited

Deep learning-enabled scaffolding of spatial arrays of PfCSP epitopes

Nelson R. Wu, Karla M. Castro, Nathan Beutler, Wen-Hsin Lee, Sai Sundar Rajan Raghavan, Gregory M. Martin, Monika Jain, Sashank Agrawal, Alessia Liguori, Oleksandr Kalyuzhniy, Patrick D. Skog, Sierra Terada, Yen‐Chung Lai, Justin Ndihokubwayo, Danny Lu, , William R. Schief

This study uses deep learning to design multi-epitope scaffolds mimicking CSP's spatial structure, showing accurate positioning of two epitopes and partial success with the third.

Proceedings of the National Academy of Sciences · Apr 7, 2026Peer-reviewedImmunology

Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens

Gregory M. Martin, Rebecca A Russell, Philipp Mundsperger, Scarlett L Harris, Lu Jovanoska, Luiza Farache Trajano, Torben Schiffner, Katalin Fabian, Monica Tolazzi, Gabriella Scarlatti, Leon R. McFarlane, Hannah M. Cheeseman, Yoann Aldon, Edith E. Schermer, Mariëlle J. van Breemen, , Quentin James Sattentau

This study shows that chemical cross-linking with EDC stabilizes HIV-1 Env trimers without significant structural distortion, improving their stability, morphology, antigenicity, and immunogenicity for vaccine development.

npj Vaccines · Jul 13, 2023Peer-reviewedMolecular Biology