Lei Wang

Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells

This study benchmarks and optimizes Perturb-seq in human pluripotent stem cells, identifying shared regulatory networks during cardiomyocyte differentiation.

Evolution of BA.2.86 to JN.1 reveals functional changes in non-structural viral proteins are required for fitness of SARS-CoV-2

This study investigates the evolutionary changes from BA.2.86 to JN.1, showing that non-spike protein mutations compensate for reduced spike protein replication, enhancing viral fitness.

Chicken shank color determined by Inhibition of dermal melanin (ID) is mediated by a structural variation regulating CDKN2A expression

This study identifies a structural variation in the CDKN2A gene that regulates shank color in chickens by inhibiting dermal melanin production.

Epithelial IL-2 is critical for NK cell-mediated cancer immunosurveillance in mammary glands

The paper identifies epithelial IL-2 as critical for maintaining NK cell function in mammary glands, leading to improved immunosurveillance and prevention of tumor development.

Large scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal crosstalk

This paper develops an optimized protocol for large-scale production of human blastoids and identifies signaling pathways and endometrial stromal effects in blastocyst development.

Large-scale gene losses underlie the genome evolution of parasitic plant Cuscuta australis

The paper presents the genome of Cuscuta australis, revealing gene losses and evolutionary adaptations linked to its parasitic lifestyle.