Meng Wang

Hierarchical chromatin polyvalency governs robust gene regulation and organogenesis

The paper shows that H2Aub, not H3K27me3, is the main repressor in chromatin polyvalency, and its disruption causes organogenesis defects in mouse embryos.

Spatially resolved cellular and circuit architecture of the insular cortex controlling different dimensions of pain

The paper maps the spatial organization and functional circuits of the insular cortex involved in different pain dimensions using MERFISH and functional analyses.

Decoding stage-specific functions of PRC2 uncovers a cell-autonomous role in preimplantation development and a non-cell-autonomous role in primordial germ cell fate

This study reveals stage-specific PRC2 functions in preimplantation development and PGC fate through epigenetic dynamics and intercellular communication.

High-resolution dissection of human cell type-specific enhancers in cis and trans activities

This study identifies cell type-specific enhancers by analyzing cis and trans activities using ChIP-STARR-seq in two human cell lines.

The transcription factor GABPA is a master regulator of naive pluripotency

This study identifies GABPA as a master regulator of naive pluripotency by showing its role in EPI specification and regulation of 47% of EPI genes during the E3.5 to E4.5 transition.

Tn5 transposase-based epigenomic profiling methods are prone to open chromatin bias

This paper shows that Tn5 transposase-based epigenomic methods introduce open chromatin bias, leading to false positives and misinterpretation of results.

MosaicBase: A Knowledgebase of Postzygotic Mosaic Variants in Noncancer Diseases and Asymptomatic Human Individuals

MosaicBase is a database of postzygotic mosaic variants in noncancer diseases and asymptomatic individuals, revealing distinct genomic features of disease-causing variants.

An exact transformation for CNN kernel enables accurate sequence motif identification and leads to a potentially full probabilistic interpretation of CNN

This paper introduces an exact transformation to convert CNN kernels to PWMs, enabling accurate motif identification and preserving CNN performance.