Author

Xuhong H. Qian

East China Normal UniversityORCID 0000-0001-6777-0673Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Shiliang LiiD· 2 shared Zhenjiang ZhaoiD· 2 shared Asuka InoueiD· 1 shared Bernard OfosuheneiD· 1 shared Chang LiuiD· 1 shared Chen Qiu· 1 shared Di ChangiD· 1 shared Fang YeiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Shiliang LiORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 2, 2025

Contrastive Learning-Enhanced Drug Metabolite Prediction Drives the Discovery of an Orally Bioavailable RSK4 Inhibitor for Esophageal Cancer

Huan He, Manzhan Zhang, Xiaoxiao Yang…·Shiliang Li

The paper develops ConMeter, a metabolite prediction model, and uses it to design an orally bioavailable RSK4 inhibitor with improved bioavailability and anti-tumor efficacy against esophageal cancer.

2 citations

humanmetabolomics

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BiochemistrybioRxivPreprintMar 2, 2024

Structural insights into sphingosine 1-phosphate receptor 4 activation

Wei Gao, Shiyi Gan, Mengting Zhang…·Honglin Li

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

1 citation

humancryo-EM

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