Bernd Jürgen Pichler

This paper develops nanobodies targeting hOX40 for in vivo imaging of activated T cells, showing they bind specifically and function as imaging probes without affecting T cell viability.

This study uses simultaneous fPET/fMRI to show that optogenetic stimulation suppresses nigrostriatal pathway activity through presynaptic autoinhibition, revealing a dissociation between BOLD signal depression and neuronal inactivity.

This study uses PET/fMRI in rats to show MDMA causes global hemodynamic decreases and localized metabolic increases, indicating neurovascular uncoupling due to serotonin transporter occupancy.

This study combines CRISPR/Cas9 gene editing with in vivo imaging to explore the impact of VMAT2 gene disruption on brain function and connectivity in rats.

The paper examines the relationship between dopamine D2 receptor and serotonin transporter availabilities in rats and their correlation with resting-state functional connectivity networks.

The paper analyzes longitudinal FDG-PET data to identify interregional causal influences of aging on brain metabolic activity, revealing how aging spreads across brain regions.