Tudor M. Ionescu

Hippocampal CA2 Inhibition Disrupts Prefrontal and Thalamic Connectivity

This study shows that inhibiting hippocampal CA2 neurons disrupts prefrontal and thalamic connectivity and impairs social behavior.

Long-term adaptation of prefrontal circuits in a mouse model of NMDAR hypofunction

This study investigates the long-term effects of subchronic PCP treatment on prefrontal circuits in mice, revealing alterations in cognitive performance, gamma oscillations, and synaptic connectivity associated with schizophrenia endophenotypes.

Mapping Serotonergic Dynamics using Drug-Modulated Molecular Connectivity

This study maps serotonergic dynamics using drug-modulated molecular connectivity to show changes in serotonin transporter occupancy and functional brain network after MDMA exposure.

Active Suppression of the Nigrostriatal Pathway during Optogenetic Stimulation Revealed by Simultaneous fPET/fMRI

This study uses simultaneous fPET/fMRI to show that optogenetic stimulation suppresses nigrostriatal pathway activity through presynaptic autoinhibition, revealing a dissociation between BOLD signal depression and neuronal inactivity.

StandardRat: A multi-center consensus protocol to enhance functional connectivity specificity in the rat brain

StandardRat improves functional connectivity specificity in rat brains through a standardized MRI protocol tested across 20 centers.

Neurovascular Uncoupling: Multimodal Imaging Delineates the Acute Effects of MDMA

This study uses PET/fMRI in rats to show MDMA causes global hemodynamic decreases and localized metabolic increases, indicating neurovascular uncoupling due to serotonin transporter occupancy.

Combining CRISPR/Cas9 and brain imaging: from genes to molecules to networks

This study combines CRISPR/Cas9 gene editing with in vivo imaging to explore the impact of VMAT2 gene disruption on brain function and connectivity in rats.

Striatal and prefrontal D2R and SERT distributions contrastingly correlate with default-mode connectivity

The paper examines the relationship between dopamine D2 receptor and serotonin transporter availabilities in rats and their correlation with resting-state functional connectivity networks.

Interregional causal influences of brain metabolic activity reveal the spread of aging effects during normal aging

The paper analyzes longitudinal FDG-PET data to identify interregional causal influences of aging on brain metabolic activity, revealing how aging spreads across brain regions.