Ulrich Rothbauer

This paper introduces NanoBlocks, a method to convert affinity binders into fluorescent biosensors by adding competitive peptides, demonstrating their use in detecting targets in vitro and in cells.

The paper visualizes β-catenin localization during Xenopus nephron development and finds that it becomes enriched at epithelial junctions while remaining in nuclear and cytoplasmic compartments during maturation.

This study uses single-molecule tracking to show that Lrp6 and Ror2 co-assemble into hybrid Wnt signalosomes dynamically.

This paper develops nanobodies targeting hOX40 for in vivo imaging of activated T cells, showing they bind specifically and function as imaging probes without affecting T cell viability.

This study develops nanobodies to monitor Drp1, a mitochondrial fission factor, using proteomics, microscopy, and live-cell imaging techniques to study its dynamics in disease models.