Ezra S. Lencer

The paper identifies direct transcriptional targets of Prdm3 and Prdm16 in zebrafish neural crest cells using CUT&RUN and shows altered gene expression in mutants.

The paper shows that Gq/11 signaling mediates lower jaw development in zebrafish by restoring jaw structures and gene expression in Edn1-deficient embryos.

The paper tests whether PRDM1 variants associated with SHFM can rescue craniofacial defects in prdm1a-/- zebrafish, finding they do not, and shows Prdm1a regulates craniofacial genes.

The paper identifies PRDM1 variants causing Split Hand/Foot Malformation and shows their functional impact on limb development through zebrafish experiments and gene expression analysis.

This study shows that cdon and boc synergistically promote hedgehog signaling in zebrafish, affecting neural crest cell migration through slow-twitch muscle and extracellular matrix defects.

The paper uses single-cell RNA sequencing to identify pre-migratory neural crest cell populations in zebrafish and their associated gene markers.

This study shows that Prdm3 and Prdm16 regulate Wnt/β-catenin activity to control craniofacial chondrocyte differentiation and development.

The paper identifies transcriptional targets of KMT2D and KDM6A in Kabuki Syndrome patients and compares their effects across human, mouse, and zebrafish datasets.