Kristin Artinger

Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit

The paper identifies a core regulatory circuit in rhabdomyosarcoma and shows that targeting two co-activators synergistically inhibits tumor growth.

PRDM3 and PRDM16 define cranial neural crest cell states in zebrafish development

The paper identifies direct transcriptional targets of Prdm3 and Prdm16 in zebrafish neural crest cells using CUT&RUN and shows altered gene expression in mutants.

PRDM16 is necessary for sensory neuronal development in the Trigeminal Ganglion

This study shows PRDM16 is essential for trigeminal ganglion development and sensory neuron differentiation in zebrafish and mice.

PRDM paralogs are required for Meckel's cartilage formation during mandibular bone development

This study shows PRDM3 and PRDM16 are essential for Meckel's cartilage formation by regulating Wnt/β-catenin signaling during neural crest cell differentiation in mice.

SPLIT HAND/FOOT VARIANTS FAIL TO RESCUE PRDM1A MUTANT CRANIOFACIAL DEFECTS

The paper tests whether PRDM1 variants associated with SHFM can rescue craniofacial defects in prdm1a-/- zebrafish, finding they do not, and shows Prdm1a regulates craniofacial genes.

PRDM1 DNA-binding zinc finger domain is required for normal limb development and is disrupted in Split Hand/Foot Malformation

The paper identifies PRDM1 variants causing Split Hand/Foot Malformation and shows their functional impact on limb development through zebrafish experiments and gene expression analysis.

cdon and boc affect trunk neural crest cell migration non-cell autonomously through a reduction of hedgehog signaling in zebrafish slow-twitch muscle

This study shows that cdon and boc synergistically promote hedgehog signaling in zebrafish, affecting neural crest cell migration through slow-twitch muscle and extracellular matrix defects.

Single cell RNA analysis of trunk neural crest cells in zebrafish identifies pre-migratory populations expressing markers of differentiated derivatives

The paper uses single-cell RNA sequencing to identify pre-migratory neural crest cell populations in zebrafish and their associated gene markers.

PRDM proteins control Wnt/β-catenin activity to regulate craniofacial chondrocyte differentiation

This study shows that Prdm3 and Prdm16 regulate Wnt/β-catenin activity to control craniofacial chondrocyte differentiation and development.

The role of Kabuki Syndrome genes KMT2D and KDM6A in development: Analysis in Human sequencing data and compared to mice and zebrafish

The paper identifies transcriptional targets of KMT2D and KDM6A in Kabuki Syndrome patients and compares their effects across human, mouse, and zebrafish datasets.

The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development

This study examines the roles of Prdm3 and Prdm16 in craniofacial development across zebrafish and mice, revealing conserved and divergent functions in gene regulation and epigenetic modifications.