Thomas Haynes Hutson

This study identifies neuronal architectures responsible for autonomic dysreflexia after spinal cord injury and demonstrates how epidural stimulation can counteract it in mice, rats, and humans.

This study identifies circadian rhythms as a key regulator of axonal regenerative ability in DRG neurons, showing that clock genes like Bmal1 are essential for regeneration and that chrono-active drugs like lithium can enhance nerve repair.

The paper introduces the Tabulae Paralytica, a multimodal atlas of spinal cord injury, revealing biological principles and developing a gene therapy to restore walking in old mice.

This study evaluates differential expression methods in single-cell transcriptomics, finding that many produce false discoveries due to ignoring biological variation.

The paper introduces a machine-learning method, Augur, to identify cell types most responsive to biological perturbations in single-cell data and validates it on multiple datasets.

The paper identifies PP4-dependent HDAC3 dephosphorylation as a mechanism distinguishing axonal regeneration from regenerative failure in nerve injuries.