The circadian clock is a pacemaker of the axonal regenerative ability
Francesco De Virgiliis, Franziska Müller, Ilaria Palmisano, Jessica Chadwick, Lucia Luengo-Gutierrez, Angela Giarrizzo, Yuyang Yan, Matt Christopher Danzi, Carmen Picón Muñoz, Luming Zhou, Guiping Kong, Elisabeth Serger, Thomas Haynes Hutson, ines Maldonado, Yayue Song, , Simone Di Giovanni
This study identifies circadian rhythms as a key regulator of axonal regenerative ability in DRG neurons, showing that clock genes like Bmal1 are essential for regeneration and that chrono-active drugs like lithium can enhance nerve repair.
bioRxiv · Aug 7, 2023 · PreprintNeuroscience