Author

Huasen Jiang

Ocean University of ChinaORCID 0000-0001-6802-1017Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Jie Nie· 2 shared Shugang ZhangiD· 2 shared Wenjian MaiD· 2 shared Xiangpeng BiiD· 2 shared Zhiqiang Wei· 2 shared Henggui ZhangiD· 1 shared Jiaxin LiniD· 1 shared Rui Chen· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBioinformatics

Jie Nie

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2 papers

Recent·Most cited

Deciphering Mechanistic Signatures in Drug-Drug Interactions with Dual Topology Graphs

Wenjian Ma, Xiangpeng Bi, Huasen Jiang, Weigang Lu, Jie Nie, Shutan Lin, Jiaxin Lin, Zhiqiang Wei, Henggui Zhang, Shugang Zhang

This paper introduces DualTopoDDI, a deep learning model for predicting drug-drug interactions with mechanistic insights, achieving high accuracy and interpretability.

bioRxiv · Sep 24, 2026 · PreprintBioinformatics

Predicting Protein-RNA Binding Affinity Changes via Spatial Coupling-Aware State Space Modeling

Rui Chen, Xiaoyu Huang, Huasen Jiang, Wenjian Ma, Xiangpeng Bi, Zhiqiang Wei, Jie Nie, Shugang Zhang

iSCALE predicts mutation-induced changes in protein-RNA binding affinity using a spatial coupling-aware deep learning model, achieving superior performance on multiple binding affinity tasks.

bioRxiv · Aug 24, 2026 · PreprintBioinformatics