Author

Shugang Zhang

Ocean University of ChinaORCID 0000-0002-9774-9709Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Huasen JiangiD· 2 shared Jie Nie· 2 shared Wenjian MaiD· 2 shared Xiangpeng BiiD· 2 shared Zhiqiang Wei· 2 shared Ashok Kumar SalujaiD· 1 shared Chao GaoiD· 1 shared Chenyang ZhaoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBioinformatics

Huasen JiangORCID

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Author profile →

3 papers

Recent·Most cited

Deciphering Mechanistic Signatures in Drug-Drug Interactions with Dual Topology Graphs

Wenjian Ma, Xiangpeng Bi, Huasen Jiang, Weigang Lu, Jie Nie, Shutan Lin, Jiaxin Lin, Zhiqiang Wei, Henggui Zhang, Shugang Zhang

This paper introduces DualTopoDDI, a deep learning model for predicting drug-drug interactions with mechanistic insights, achieving high accuracy and interpretability.

bioRxiv · Sep 24, 2026 · PreprintBioinformatics

Predicting Protein-RNA Binding Affinity Changes via Spatial Coupling-Aware State Space Modeling

Rui Chen, Xiaoyu Huang, Huasen Jiang, Wenjian Ma, Xiangpeng Bi, Zhiqiang Wei, Jie Nie, Shugang Zhang

iSCALE predicts mutation-induced changes in protein-RNA binding affinity using a spatial coupling-aware deep learning model, achieving superior performance on multiple binding affinity tasks.

bioRxiv · Aug 24, 2026 · PreprintBioinformatics

Epithelial FOXP3 Drives Pancreatic Fibrosis through O-glycosylated IL-6

Ruining Gong, Minghan Ren, Junjin Wang, Wenqing Zhang, Shuai Ping, Ke Lei, Qian Yu, Leina Ma, Chao Gao, Chenyang Zhao, Shunli Fu, Jing Xue, Jigang Wang, Hao Sun, Jinsuo Chen, , He Ren

This study identifies epithelial FOXP3 as a driver of pancreatic fibrosis through O-glycosylation of IL-6, revealing a novel mechanism in fibrocarcinogenesis.

bioRxiv · Nov 19, 2025 · PreprintCancer Biology