Author

Xiangpeng Bi

Ocean University of ChinaORCID 0000-0003-4712-0870Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Huasen JiangiD· 2 shared Jie Nie· 2 shared Shugang ZhangiD· 2 shared Wenjian MaiD· 2 shared Zhiqiang Wei· 2 shared Henggui ZhangiD· 1 shared Jiaxin LiniD· 1 shared Rui Chen· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBioinformatics

Huasen JiangORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintSep 24, 2026

Deciphering Mechanistic Signatures in Drug-Drug Interactions with Dual Topology Graphs

Wenjian Ma, Xiangpeng Bi, Huasen Jiang…·Shugang Zhang

This paper introduces DualTopoDDI, a deep learning model for predicting drug-drug interactions with mechanistic insights, achieving high accuracy and interpretability.

DOI 10.64898/2026.09.23.753684

deep learningdrug response / drug discovery

𝕏 PostBluesky

BioinformaticsbioRxivPreprintAug 24, 2026

Predicting Protein-RNA Binding Affinity Changes via Spatial Coupling-Aware State Space Modeling

Rui Chen, Xiaoyu Huang, Huasen Jiang…·Shugang Zhang

iSCALE predicts mutation-induced changes in protein-RNA binding affinity using a spatial coupling-aware deep learning model, achieving superior performance on multiple binding affinity tasks.

DOI 10.64898/2026.08.23.745486

protein structuredeep learning

𝕏 PostBluesky