Xiaoyu Huang

iSCALE predicts mutation-induced changes in protein-RNA binding affinity using a spatial coupling-aware deep learning model, achieving superior performance on multiple binding affinity tasks.

This study shows that XRCC1 facilitates PARP1-mediated recruitment of PARP2 to DNA damage sites through PAR binding and interaction with PARP2.

The paper shows that inactive PARP2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts, explaining PARPi-induced hematological toxicities.