Author

Hengyi Li

Yale UniversityORCID 0000-0001-6807-7432Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:metagenomics· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

Claudio R. AlarcóniD· 3 shared Daryl E. KleiniD· 3 shared Marcelo Pérez-PepeiD· 2 shared Sofia Alarcon-Frias· 2 shared Tongqing LiiD· 2 shared Yansheng LiuiD· 2 shared Alexander NguyeniD· 1 shared Anthony W. DesotelliD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMolecular Biology

Claudio R. AlarcónORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

BiophysicsbioRxivPreprintSep 18, 2026

Structural Basis for MCAM Mediated Inhibition of Laminin Dependent Cell Migration

Tongqing Li, Sofia Alarcon-Frias, Hengyi Li…·Daryl E. Klein

This study determines the structural basis of MCAM-mediated inhibition of laminin-dependent cell migration by showing MCAM and integrin compete for a shared laminin interface.

DOI 10.64898/2026.09.11.751044

humancryo-EM

𝕏 PostBluesky

Molecular BiologyMolecular CellPeer-reviewedJul 31, 2026

METTL3 promotes cell cycle progression via activation of transcriptional elongation.

Azime Akçaöz-Alasar, Yanhua Wang, Hang Li…·Claudio R. Alarcón

The paper shows that METTL3 phosphorylation by CDK1 promotes transcriptional elongation and cell cycle progression through the m6A/7SK/P-TEFb axis.

DOI 10.1016/j.molcel.2026.07.011

humanmetagenomics

𝕏 PostBluesky

BiophysicsNature CommunicationsPeer-reviewedJan 18, 2025

Physical basis for the interaction between Drosophila ROS1 and the GPCR BOSS

Jianan Zhang, Yuko Tsutsui, Hengyi Li…·Daryl E. Klein

This study determines the structure of Drosophila ROS1's extracellular region bound to BOSS, revealing a hydrophobic interaction and beta-strand augmentation mechanism.

4 citations

Drosophilastructural biology

𝕏 PostBluesky

Molecular BiologybioRxivPreprintOct 17, 2022

7SK methylation Promotes Transcriptional Activity

Marcelo Pérez-Pepe, Anthony W. Desotell, Hengyi Li…·Claudio R. Alarcón

The paper shows that m6A methylation of 7SK RNA promotes transcriptional activity in response to growth factor stimulation by releasing the HEXIM1/P-TEFb complex.

DOI 10.1101/2022.10.17.512631

humanmetagenomics

𝕏 PostBluesky