Author

Yuko Tsutsui

Indian Institute of Technology GuwahatiORCID 0000-0002-3286-3295Unclaimed ORCID profile · follow to get notified of new preprints

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Yuko Tsutsui1 paper

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Kumar Dilip AshtekariD· 2 shared Mark A. LemmoniD· 2 shared Debdas DhabaliD· 1 shared Hrishabh Singh· 1 shared Keshav PatiliD· 1 shared Krishna SureshiD· 1 shared Ravi RadhakrishnaniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

Kumar Dilip AshtekarORCID

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2 papers

Recent·Most cited

EGFR and tyrosine kinase inhibitor interactions probed by hydrogen-deuterium exchange and mass spectrometry (HDX-MS)

Kumar Dilip Ashtekar, Mark A. Lemmon, Yuko Tsutsui

This study uses HDX-MS to analyze EGFR dynamics upon TKI binding, revealing inhibitor-dependent structural changes that correlate with side effects and covalent inhibitor selectivity.

bioRxiv · Oct 14, 2024 · PreprintBiophysics

Coupled Solvent and Protein Dynamics Confer Differences in Exon-19 Deletion Mutants of the Epidermal Growth Factor Receptor Kinase

Keshav Patil, Debdas Dhabal, Kumar Dilip Ashtekar, Yuko Tsutsui, Krishna Suresh, Hrishabh Singh, Mark A. Lemmon, Ravi Radhakrishnan

This study identifies two mutation profiles in EGFR Exon-19 deletions that correlate with differential TKI sensitivity through analysis of conformational dynamics and solvent interactions.

bioRxiv · Oct 4, 2024 · PreprintBiophysics