John R. Sinnamon

This study uses RNA base editing to repair a mutation in a mouse model of Rett syndrome, restoring MeCP2 function in hippocampal neurons.

The paper presents a single-cell chromatin accessibility map of the mouse hippocampus using sci-ATAC-seq, identifies cell-type-specific regulatory networks, and provides a resource for future studies.

The paper introduces sci-MET, a scalable single-cell DNA methylation sequencing method, achieving 69% read alignment rates and successfully deconvolving a mixture of three human cell lines.