Ryan M. Mulqueen

The paper introduces txci-ATAC-seq, a high-throughput single-cell ATAC-seq method, and demonstrates its application across multiple tissues and genetic backgrounds.

This paper introduces a novel adaptor-switching strategy, s3, that significantly improves usable reads per cell in single-cell genomics assays while maintaining high-throughput capabilities.

The paper introduces sciMAP-ATAC, a method for spatially resolved single-cell chromatin accessibility profiling, and applies it to study cortical lamination, spatial trajectories, and ischemic infarct progression in mouse and human tissues.

The paper introduces an improved single-cell ATAC-seq method, scip-ATAC-seq, which enhances chromatin dynamics analysis in human corticogenesis organoids.

The paper presents a single-cell chromatin accessibility map of the mouse hippocampus using sci-ATAC-seq, identifies cell-type-specific regulatory networks, and provides a resource for future studies.

The paper introduces sci-MET, a scalable single-cell DNA methylation sequencing method, achieving 69% read alignment rates and successfully deconvolving a mixture of three human cell lines.

The paper investigates exonic mosaic mutations in autism spectrum disorder (ASD) using whole-exome sequencing data from the Simons Simplex Collection, finding significant synonymous SMM burden and enrichment in chromatin modifiers.