Gail Mandel

This study maps early postnatal DNA methylation dynamics in the mouse brain, revealing subtype-specific methylation changes and their disruption in Rett syndrome.

The paper identifies unique REST binding sites in human hippocampus compared to mouse and other human cell types, suggesting species-specific roles in brain health.

This study uses RNA base editing to repair a mutation in a mouse model of Rett syndrome, restoring MeCP2 function in hippocampal neurons.

The paper presents a single-cell chromatin accessibility map of the mouse hippocampus using sci-ATAC-seq, identifies cell-type-specific regulatory networks, and provides a resource for future studies.