NeurosciencebioRxivPreprint
Reversible inhibition of medial septum interneurons abolishes initial acquisition of new place-reward associations and reveals a progressive reduction in dependence on medial septal function
Zahra Alizadeh, Janina Ferbinteanu, Michael Eckert…·Bruce L. McNaughton
This study shows that reversible inhibition of medial septum interneurons impairs initial learning of new place-reward associations but not long-term retention, suggesting a shift from hippocampus-dependent to non-hippocampus-dependent spatial strategies.
DOI 10.64898/2026.09.25.754563