Bruce L. McNaughton

This study shows that reversible inhibition of medial septum interneurons impairs initial learning of new place-reward associations but not long-term retention, suggesting a shift from hippocampus-dependent to non-hippocampus-dependent spatial strategies.

The paper shows that enriched experience in mice remodels neocortical circuits, increasing reciprocal connectivity and coding sparsity, supporting attractor network theories.

This study shows that environmental enrichment accelerates memory consolidation in mice by enhancing the stability and precision of cortical neuron activity during task learning.

This paper uses a biophysically realistic network model to show how sleep replay reorganizes synaptic-weight space to support both old and new memories.

The paper identifies a third type of dentate spike (DS3) that represents a continuous distribution of input strength from lateral and medial entorhinal cortex, challenging the traditional bimodal classification.

This study shows cognitive enrichment reverses spatial memory deficits in ELS mice and alters hippocampal synaptic connectivity.

The paper maps cortical GABA dynamics around hippocampal sharp-wave ripples in mice during different brain states, revealing state-dependent regional and temporal patterns of GABA signaling.

This paper shows that slow-wave sleep interleaves replay of familiar and novel memory traces, enabling new memories to integrate into existing cortical memory without interference.

The paper investigates how non-spatial and spatial memory representations in the cortex interact with hippocampal activity during memory consolidation, showing that non-spatial attributes precede spatial reactivation.

The paper investigates neocortical activity during hippocampal ripples in awake mice, finding that deactivation and activation dominate post-ripple activity, with distinct subpopulations of neurons showing opposing firing rate changes.

The paper identifies regional differences in cholinergic terminal activity associated with slow-wave activity in specific cortical areas during REM sleep in mice.

This paper proposes a predictive learning rule for neurons based on minimizing metabolic cost and maximizing blood supply impact, validated through simulations and animal data.

This study compares spatiotemporal patterns of spontaneous and sensory-evoked cortical activity in mice, finding differences in propagation complexity, speed, and direction.

This study examines how hippocampal sharp-wave ripples and slow-waves interact to coordinate neural activity during sleep in humans.

The paper investigates hippocampal-cortical interactions during sleep in a mouse model of Alzheimer’s disease and finds reduced SWR-DW coupling correlates with impaired spatial memory.

The paper uses artificial neural networks to model how consistency with prior knowledge affects memory integration speed and efficiency in hierarchical structures.

This paper introduces a high-density CMOS scanning probe for neural recording, demonstrating its ability to capture neural activity across multiple brain regions with improved resolution compared to lower density devices.

The paper investigates neocortical activity patterns around hippocampal sharp-wave ripples in mice, finding that neocortical activation can precede SWRs and may trigger hippocampal reactivation.

The paper introduces RatHat, a 3D-printable stereotaxic system for rat brain implants that reduces costs, training, and surgical time while improving repeatability and durability.

This study shows that low acetylcholine during early sleep supports motor memory consolidation, as increasing acetylcholine impairs motor skill retention.

The paper investigates spatial reorientation deficits in 3xTg-AD mice, finding impaired performance in female mice but not males, suggesting a sex-dependent effect of AD on spatial orientation.

The paper investigates laminar organization of motion encoding and memory reactivation in parietal cortex using multi-site recordings in rats.

This paper introduces a hyperdrive microelectrode array for simultaneous multi-site electrophysiological recording and wide-field optical imaging in mouse cortex, demonstrating its use in analyzing local and global cortical activity.