Molecular BiologybioRxivPreprint
A POLR3B-variant reveals a Pol III transcriptome response dependent on La protein/SSB
Sandy Mattijssen, Kyra Kerkhofs, Joshi Stephen…·Richard J Maraia
The paper identifies a POLR3B variant causing mis-splicing and altered Pol III transcriptome, revealing La protein's role in reshaping small ncRNA profiles and identifying tRF-1/tRF-3 as biomarkers for POLR3 deficiency.
DOI 10.1101/2024.02.05.577363